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Immune-based Strategies For Treatment And Prevention Of Hepatitis C Virus Infection
Author: Fatma Abdelaziz Amer, Marwa Abdelazim Mansour, Shymaa Abdelazim Mansour
Publisher: Internet Medical Publishing
15 pages
One time payment: €0.00
Required subscription: Free
Type of publication: Article
DOI: 10.3823/743
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According to the current epidemiological studies, 3% of the world population is infected with hepatitis C virus (HCV). The gold standard of therapy, at this time, is neither effective in a high percentage of patients, nor with all genotypes. Furthermore, it is associated with significant side effects and high cost.Therefore, new therapeutic strategies have been investigated, or in the early process of development.

These include:direct acting antiviral agents (DAAs) and immune- based therapy. Four DAA molecules have been already approved by the FDA. Immune based therapy aims at augmenting host immunity, thus prevention of infection, and clearance of the virus in subsequent reinfection.

Boosting T cell responses and activating humoral immune reaction have been targeted in the development of novel fighting tools. The most intensively studied immunetherapeutic strategies are: 1) vaccines; either therapeutic or prophylactic, 2) dendritic cells (DCs) immunotherapy, 3) antagonists of T cell inhibitory factors, 4) anti-HCV neutralizing antibodies (nAbs), 5) antagonists for Tolllike receptors (TLRs), and 6) caspase inhibitors.


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iMedPub Limited is a publishing house registered in UK, publishing medical books and journals since 2005. As an open service to doctors and biomedical researchers, it is driven by clinicians and researchers for themselves, while serving the interests of the general public. iMedPub disseminates research in a tiered system, beginning with our specialty books and journals and then working upwards. The grand vision of iMedPub is a world where all medical researchers and health professionals have an equal opportunity to seek, share and create knowledge. As we are a low cost academic publisher we offer the lowest article processing charges of all biomedical journals and publish books free of charges for authors.

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