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The CTX-M type enzymes have become the most prevalent extended spectrum β-lactamases (ESBLs) worldwide. Among the CTX-M type enzymes, CTX-M-15 is the most widespread and has been reported from all continents. It has been recovered from different Enterobacteriaceae and has been isolated from both community and hospital acquired infections. This review primarily highlights the prevalence of CTX- M-15 in addition to other ESBLs in the Middle East. Detection of any type of ESBL is of importance in therapeutic treatment.
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