Pharmacophore Modeling: Advances, Limitations, ...

Distribution Of Bla Oxa-23 , Is Aba , Aminogly...

Structure-based Three-dimensional Pharmacophore...

0 votes
Structure-based Three-dimensional Pharmacophores As An Alternative To Traditional Methodologies
Author: Anand Gaurav, Vertika Gautam
Publisher: Derivative Works
12 pages
One time payment: €0.00
Required subscription: Free
Type of publication: Article
ISBN/ISSN: 1178-699X
DOI: 10.2147/JRLCR.S46845
Follow this publisher

Share this publication:


Abstract: Structure-based pharmacophore approaches have become widely used in drug discovery and design. This can be attributed to the development of new tools and methods over the past decade. Various tools based on different premises have been developed, including active site information in traditional pharmacophores. These tools have been widely used in virtual screening, de novo design, and lead optimization and been proven to be highly successful. Studies based on simultaneous use of structure-based pharmacophores, ligand-based pharmacophores, and docking have also come into the picture recently. Here, the development of structure-based pharmacophores as an alternative to traditional drug discovery approaches is discussed, with emphasis on the advances and latest developments in tools and success stories involving their application.

About the publisher:

We are a publishing house devoted to reuse CC-BY licensed published materials.


Using CC-BY licenses:


  • Adapt — remix, transform, and build upon the material
  • for any purpose, even commercially.
  • The licensor cannot revoke these freedoms as long as you follow the license terms.


  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others
    from doing anything the license permits.


  • You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
  • No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

Select a payment method