Recommended

Incorporating Alternative Design Clinical Trial...

The Importance Of The Quadruped Animal Model In...

Pain Test Sensitivity To Morphine Analgesia

Legionella Native Valve Endocarditis Case Repor...

How Valid Are Commercially Available Medical Si...

0 votes
Endothelin System And Pain
Author: Terika P Smith, Tami Haymond, Sherika N Smith, Sarah M Sweitzer
Publisher: MARTÍN SÁNCHEZ BERTA
15 pages
One time payment: €0.00
Required subscription: Free
Type of publication: Article
ISBN/ISSN: 1178-7090
DOI: 10.2147/65923
Follow this publisher

Share this publication:

Description:

Abstract: Many people worldwide suffer from pain and a portion of these sufferers are diagnosed with a chronic pain condition. The management of chronic pain continues to be a challenge, and despite taking prescribed medication for pain, patients continue to have pain of moderate severity. Current pain therapies are often inadequate, with side effects that limit medication adherence. There is a need to identify novel therapeutic targets for the management of chronic pain. One potential candidate for the treatment of chronic pain is therapies aimed at modulating the vasoactive peptide endothelin-1. In addition to vasoactive properties, endothelin-1 has been implicated in pain transmission in both humans and animal models of nociception. Endothelin-1 directly activates nociceptors and potentiates the effect of other algogens, including capsaicin, formalin, and arachidonic acid. In addition, endothelin-1 has been shown to be involved in inflammatory pain, cancer pain, neuropathic pain, diabetic neuropathy, and pain associated with sickle cell disease. Therefore, endothelin-1 may prove a novel therapeutic target for the relief of many types of chronic pain.

Select a payment method