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Paroxysmal Nocturnal Hemoglobinuria: Report Of Suboptimal Response To The Use Of Eculizumab
Author: Ricardo Parente Garcia Vieira, Lucas Parente Alencar, George Nilton Nunes Mendes, Natália Parente Alencar, Francisco Rômulo Patrício De Sá, Hermes Melo Teixeira Batista, Jully Graziela Coelho Campos Couto, José Lucas Souza Ramos, Thiáskara Rami
Publisher: Internet Medical Publishing
5 pages
One time payment: €0.00
Required subscription: Free
Type of publication: Article
DOI: 10.3823/1754
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The Paroxysmal Nocturnal Hemoglobinuria (PNH) is an acquired clonal disorder of one or more stem cells of hematopoietic lineage. It is characterized as a chronic hemolytic anemia in which there is a persistent intravascular hemolysis which is subject to exacerbations due to production of subpopulations of erythrocytes, platelets and granulocytes hypersensitive to complement. Furthermore there has been a high tendency to thrombosis. The anti-complement therapy is the only recognized treatment for this condition. We reporta case of PNH with suboptimal response to anti-complement therapy.

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