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Cancer Testis Antigen And Immunotherapy
Author: Deepa Kolaseri Krishnadas, Fanqi Bai, Kenneth G Lucas
Publisher: Derivative Works
9 pages
One time payment: €0.00
Required subscription: Free
Type of publication: Article
ISBN/ISSN: 2253-1556
DOI: 10.2147/35570
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Abstract: The identification of cancer testis (CT) antigens has been an important advance in determining potential targets for cancer immunotherapy. Multiple previous studies have shown that CT antigen vaccines, using both peptides and dendritic cell vaccines, can elicit clinical and immunologic responses in several different tumors. This review details the expression of melanoma antigen family A, 1 (MAGE-A1), melanoma antigen family A, 3 (MAGE-A3), and New York esophageal squamous cell carcinoma-1 (NY-ESO-1) in various malignancies, and presents our current understanding of CT antigen based immunotherapy.

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