Recommended

Multiplexed Digital Mrna Profiling Of The Infla...

Mycobacterium Bovis In Burkina Faso: Epidemiolo...

A Putative Antiviral Role Of Plant Cytidine Dea...

Vector Competence In West African Aedes Aegypti...

Qtl Mapping Of Genome Regions Controlling Temep...

0 votes
A Putative Antiviral Role Of Plant Cytidine Deaminases
Author: Susana Martín, José M. Cuevas, Ana Grande-pérez & Santiago F. Elena
Publisher: Derivative Works
19 pages
One time payment: €0.00
Required subscription: Free
Type of publication: Article
ISBN/ISSN: https://www.google.es/?gfe_rd=cr&ei=i1KyVKDJOYet8wfr84CoBg#q=bioRxiv+issn
DOI: 10.1101/005256
Follow this publisher

Share this publication:

Description:

A mechanism of innate antiviral immunity operating against viruses infecting mammalian cells has been described during the last decade. Host cytidine deaminases (e.g., APOBEC3 proteins) edit viral genomes giving raise to hypermutated nonfunctional viruses; consequently, viral fitness is reduced through lethal mutagenesis. By contrast, sub-lethal hypermutagenesis may contribute to virus evolvability by increasing population diversity. To prevent genome editing, some viruses have evolved proteins that mediate APOBEC3 degradation. The model plant Arabidopsis thaliana encodes for nine cytidine deaminases (AtCDAs), raising the question of whether deamination is an antiviral mechanism in plants as well. Here we tested the effects of AtCDAs expression on the pararetrovirus Cauliflower mosaic virus (CaMV). We show that A. thaliana AtCDA1 gene product exerts a mutagenic activity, which indeed generates a negative correlation between the level of AtCDA1 expression and CaMV accumulation in the plant, suggesting that deamination may also work as an antiviral mechanism in plants.

About the publisher:

We are a publishing house devoted to reuse CC-BY licensed published materials.

 

Using CC-BY licenses:

YOU ARE FREE TO:

  • Adapt — remix, transform, and build upon the material
  • for any purpose, even commercially.
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

UNDER THE FOLLOWING TERMS:

  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others
    from doing anything the license permits.

NOTICES:

  • You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
  • No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

Select a payment method