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To determine the efficacy and carryover effects of diacerein vs diclofenac in Indian population with knee osteoarthritis (OA). ut of 189 patients screened, 81 patients with painful knee OA were randomized and 77 completed the study. At 16 wks, diacerein showed superiority to both diclofenac and the combination therapy as assessed (95% CI) with 100mm VAS score (p<0.05), WOMAC scores (p<0.001), as well as LII, KSS and acetaminophen consumption (p<0.001), demonstrating the carryover effect of the drug. Intragroup comparison showed signifi cant difference in all WOMAC scores from baseline score in each group. Diacerein was safe, well tolerated and caused diarrhea as the frequent adverse effect.
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