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Metastatic Renal Cell Carcinoma: Update On Epidemiology, Genetics, And Therapeutic Modalities
Author: Angela Graves, Hannah Hessamodini, Germaine Wong, Wai H Lim
Publisher: Derivative Works
18 pages
One time payment: €0.00
Required subscription: Free
Type of publication: Article
ISBN/ISSN: 2253-1556
DOI: 102147/31426
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Description:

Abstract: The treatment of advanced renal cell carcinoma (RCC) remains a major therapeutic challenge for clinicians. Despite advances in the understanding of the immunobiology of RCC and the availability of several novel targeted agents, there has been little improvement in the survival of patients with metastatic RCC. This review will focus on the recent understanding of risk factors and treatment options and outcomes of metastatic RCC, in particular, targeted therapeutic agents that inhibit vascular endothelial growth factor and mammalian target of rapamycin pathways. Prospective studies are required to determine whether sequential targeted therapy will further improve progression-free survival in RCC. Ongoing research to develop novel agents with better tolerability and enhanced efficacy in the treatment of metastatic RCC is required.

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