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Multiple Sclerosis (MS) is a common demyelinating and inflammatory disease of the CNS with presumed autoimmune and multifactorial etiologies, including both environmental and multiple genetic factors . The question of heterogeneity of clinical subtypes is a crucial issue in genetics of MS that could find an explanation with the association and linkage disequilibrium of different MS subtypes with distinct alleles of the human leukocyte antigen
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