Ziv-aflibercept In Metastatic Colorectal Cancer

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Ziv-aflibercept In Metastatic Colorectal Cancer
Author: Anuj Patel, Weijing Sun
Publisher: Derivative Works
13 pages
One time payment: €0.00
Required subscription: Free
Type of publication: Article
ISBN/ISSN: 1177-5491
DOI: 10.2147/BTT.S39360
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Abstract: The combination of cytotoxic chemotherapy and antiangiogenic agents has become a conventional treatment option for patients with metastatic colorectal cancer. Ziv-aflibercept is a fusion protein which acts as a decoy receptor for vascular endothelial growth factor (VEGF)-A, VEGF-B, and placental growth factor (PlGF); it was approved in combination with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) for the treatment of patients with metastatic colorectal cancer that is resistant to or has progressed after an oxaliplatin-containing fluoropyrimidine-based regimen. Herein we review the role of tumor angiogenesis as the rationale for antiangiogenic therapy, the clinical data associated with ziv-aflibercept, and its current role as a treatment option compared to other antiangiogenic agents, such as bevacizumab and regorafenib.

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