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Epileptic Seizures In Neurodegenerative Dementia Syndromes
Author: Aj Larner
Publisher: Internet Medical Publishing
6 pages
One time payment: €6.08
Required subscription: Clinical
Type of publication: Article
DOI: 10:3823/302
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Description:

Epileptic seizures may be a feature of some neurodegenerative dementia syndromes. There is an increased incidence of seizures in Alzheimer’s disease compared to age matched controls. Seizures also occur in prion disorders and some frontotemporal lobar degeneration syndromes, whereas parkinsonian dementia disorders seem relatively seizure free.

Seizure pathogenesis in these conditions is uncertain, but may relate to neocortical and hippocampal hyperexcitability and synchronised activity, possibly as a consequence of dysfunctional protein metabolism, neuronal structural changes, and concurrent cerebrovascular disease.

Alzheimer’s disease may be a neuronalnetwork disorder, characterised by both cognitive decline and epileptic activity, in which seizures are an integral part of disease phenotype rather than epiphenomena. Treatment of seizures in dementia syndromes currently remains empirical. Greater understanding of dementia pathogenesis may shed light on mechanisms of epileptogenesis and facilitate more rational approaches to seizure treatment.

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iMedPub Limited is a publishing house registered in UK, publishing medical books and journals since 2005. As an open service to doctors and biomedical researchers, it is driven by clinicians and researchers for themselves, while serving the interests of the general public. iMedPub disseminates research in a tiered system, beginning with our specialty books and journals and then working upwards. The grand vision of iMedPub is a world where all medical researchers and health professionals have an equal opportunity to seek, share and create knowledge. As we are a low cost academic publisher we offer the lowest article processing charges of all biomedical journals and publish books free of charges for authors.

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