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Sickle Cell Disease In Sub-saharan Africa: Molecular Mechanisms Underlying Episodic Crises, Current And Emerging Therapeutic Strategies In Treatment
Author: Ajonuma Louis Chukwuemeka, Yusuf Azeez, Bamiro Adebisi Saka1, Makonjuola Samira Lobo, Ajuonuma Udochukwu Joshua, Ajuonuma Mary Uchechi, Emmanuel Blessing Chioma, Ogbedeagu Virgilus Mahakwe, Chuku Chika Lawson, Adabale Khedijat Abosede, Dosunmu Adedoy
Publisher: Internet Medical Publishing
15 pages
One time payment: €0.00
Required subscription: Free
Type of publication: Article
DOI: 10.3823/1784
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Sickle cell disease (SCD) is a haematological disease that affects multiple organs, thus eliciting episodes of chronic pain, acute anaemia and infection, due to a single nucleotide mutation in the β-globin gene, which results in the substitution of a glutamic acid residue in place of valine on the β-globin chain of the resultant haemoglobin protein molecule, the sickle haemoglobin (HbS). 

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